The more you know, the more you know you don’t know. In that sense the happiest state of affairs is when you are so ignorant you think you know everything. I guess there must be a lot of happy people out there.
Since I get a perverse joy in increasing my known ignorance it’s interesting to pick an area and see what’s up. Today I found this fascinating article on antibiotic resistance: Interactions among Strategies Associated with Bacterial Infection: Pathogenicity, Epidemicity, and Antibiotic Resistance. As science discovers more it may be possible to target new drugs so that developing resistance carries too high of a cost in terms of lost virulence, lost mutability, lost resistance to older drugs, or decreased reproductive fitness. More work on the ecological bionomic approach needs to be done as well, promoting beneficial, or at least minimally harmful, bacteria to crowd out their pathogenic relatives. Freed from the burdens of virulence and transmissibility an engineered strain should be quite competitive. At least until those little sluts trade enough genes to mess the whole thing up.
Interesting non-technical book on medical research, Testing Treatments, available as free pdf
.Authors retract paper claiming antidepressants prevent suicide. So does that mean they only cause suicide?
Something I’ve had bookmarked for years:The Speed of Life: Why Time Seems to Speed Up and How to Slow it Down
Great post on happiness, money and confusing means with ends at Pragmatic Capitalism. The list of ways to increase happiness from Montier is one of the best I’ve seen. Read it now.
Good piece from Mish on decoupling. One of the benefits of reading financial histories is discovering that decoupling hasn’t been possible for hundreds of years (if ever, based on archaeological evidence). Transmission of a crisis took longer 300 years ago but even then they eventually spread around the globe.
FDA must withdraw some livestock antibiotics, according to court ruling.
Facebook must be really getting worried about their privacy reputation, warns employers not to demand passwords.
Possible new route to fight Dengue fever. Based on this statins may provide some protection. Good news for warm weather lovers.
Comparison of Fukushima and Chernobyl health risks. But it really depends on where the ocean carries its payload.
Everolimus plus exemestane improves bone health in post-menopausal women with advanced breast cancer. It would really be a first if an immunosuppressant (mTOR inhibitor in this case) improved bone health.
How music prevents heart transplant rejection. I shudder to think what the alternative medicine crowd is going to do with something like this.