Transplant and Medical Links

Immunological Monitoring of Renal Transplant Recipients to Predict Acute Allograft Rejection Following the Discontinuation of Tacrolimus Time will tell. I find it hard to believe T cells are the only contributing factor.

Delayed mTOR Inhibition with Low Dose of Everolimus Reduces TGFβ Expression, Attenuates Proteinuria and Renal Damage in the Renal Mass Reduction Model This isn’t the first study I’ve seen with low dose mTOR having better results. But given the limited number of available agents, ensuring adequate suppression becomes a complex problem.

Rapamycin Ameliorates Kidney Fibrosis by Inhibiting the Activation of mTOR Signaling in Interstitial Macrophages and Myofibroblasts It would be great to find different targets that would allow the benefits of Rapamycin without the downward spiral that can occur from decreased wound healing combined with declining function.

Statins but Not Aspirin Reduce Thrombotic Risk Assessed by Thrombin Generation in Diabetic Patients without Cardiovascular Events: The RATIONAL Trial Statins may yet end up more a curse than a blessing in the general population but this is an interesting result in diabetic patients.

Calcineurin-Inhibitor Minimization in Liver Transplant Patients with Calcineurin-Inhibitor-Related Renal Dysfunction: A Meta-Analysis Liver transplant isn’t the highest hurdle by any means but it’s another victory for CNI minimization.

Renal Transplant Immunosuppression Impairs Natural Killer Cell Function In Vitro and In Vivo Just plain interesting. I don’t know why T cells became the glamor boys of immunity but ignoring other cell types can’t help long-term survival. Dendritic cells seem to be especially overlooked.

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