Renal Transplant News and Comment

It’s been a while since I’ve seen anything that interesting but several of these challenge some assumptions behind current practice so caught my eye.

A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection. Agents with some B-cell activity may also be important for some time after transplant.

Activation of innate immune defense mechanisms contributes to polyomavirus BK-associated nephropathy. Partial explanation for why BK is such a bitch.

Increased influx of myeloid dendritic cells during acute rejection is associated with interstitial fibrosis and tubular atrophy and predicts poor outcome. The finger of blame points to dendritic cells again.

Repeat true surveillance biopsies in kidney transplantation. More evidence that with current immunosuppressants even when things appear to be going well, they are fairly likely not.

Hepatitis E virus and the kidney in solid-organ transplant patients. No vaccine and rarely tested for means HepE is likely to spread quite well.

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